Regulated Proteolysis in Microorganisms by David A. Dougan

Author:David A. Dougan
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

Like other ATP-dependent proteases, Clp is required for both general and regulated proteolysis. General proteolysis removes damaged or excess proteins from the cell thereby ensuring protein quality and homeostasis. While several proteases perform this task in Escherichia coli and related bacteria, Clp proteases seem to be primarily responsible for degrading non-native damaged proteins in low GC Gram-positive bacteria [5]. Regulated proteolysis on the other hand is the specific and conditional degradation of regulatory proteins that allows the bacterium to control cellular adaptations and differentiations in response to extra- or intracellular signals.

To date, Clp proteases have been shown to be important for virulence in cell and animal models for a number of important Gram-positive and Gram-negative pathogens. Below we will summarize current knowledge on the molecular mechanism contributing to the importance of Clp proteases in virulence. We furthermore will cover the new and very promising field – Clp as a target of newly identified antibiotic compounds, and the use of Clp in vaccines against widespread pathogens like Salmonella enterica serovar Typhimurium and Streptococcus pneumoniae.

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